Rituximab inefficiency during type I cryoglobulinaemia
نویسندگان
چکیده
منابع مشابه
Successful Treatment of Cryoglobulinaemia with Rituximab
Cryoglobulinaemia is a systemic inflammatory condition characterised by immune complex-mediated small-to-medium-sized vasculitis. It has a wide variety of presentations ranging from bruising, neuropathy, and hepatosplenomegaly to acute renal failure. Mixed cryoglobulinaemia is the most common type and is strongly associated with hepatitis C. Management approaches include use of cyclophosphamide...
متن کاملDelayed onset of membranoproliferative glomerulonephritis in a patient with type I cryoglobulinaemia.
Key words: IgG cryoglobulinaemia; leukocytoclastic festations in their study of 21 patients with type I cryoglobulinaemia in 25% of cases. The renal mani-vasculitis; monoclonal cryoglobulinaemia; membrano-proliferative glomerulonephritis (MPGN) festations may result from massive subendothelial deposits of cryoglobulins, or diffuse glomerulonephritis with subendothelial deposits similar to those...
متن کاملRituximab for the treatment of glomerulonephritis in hepatitis C associated cryoglobulinaemia.
Mixed-type cryoglobulins are strongly associated with hepatitis C virus (HCV) infection and may lead to vasculitis with renal involvement. The treatment of this condition is antiviral therapy for HCV, but this may be ineffective or not tolerated because of side effects. Alternative strategies such as immunosuppressive drugs and plasmapheresis are of limited use, especially in patients after liv...
متن کاملType 2 diabetes in hepatitis C-related mixed cryoglobulinaemia patients.
OBJECTIVES Mixed cryoglobulinaemia (MC) is a systemic vasculitis frequently associated with hepatitis C virus (HCV) infection. A possible link between HCV infection and type 2 diabetes has been suggested. This study evaluated the prevalence and clinical phenotype of diabetes in MC-HCV+ patients. METHODS Two hundred and twenty-nine consecutively recruited MC-HCV+ patients were compared with 21...
متن کاملUnusual manifestations of type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia.
Cryoglobulinaemia in association with Waldenström's macroglobulinaemia is relatively common, ranging from 8% to 18% of cases; however, < 5% have symptoms or complications. We describe a patient with a history of cutaneous, peritoneal, and fallopian tube vasculitis related to type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia. Cytotoxic treatment was initiated (cyclophosp...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2005
ISSN: 1460-2172
DOI: 10.1093/rheumatology/keh503